Modeling Natural Anti-Inflammatory Compounds by Molecular Topology

Modeling Natural Anti-Inflammatory Compounds by Molecular Topology

One of the main pharmacological problems today in the treatment of chronic inflammation diseases consists of the fact that anti-inflammatory drugs usually exhibit side effects. The natural products offer a great hope in the identification of bioactive lead compounds and their development into drugs for treating inflammatory diseases. Computer-aided drug design has proved to be a very useful too...

Natural Anti-Inflammatory Products/Compounds: Hopes and Reality

Inflammation is a complex biological response to injury as a result of different stimuli such as pathogens, damaged cells, or irritants. Nowadays, the commercially approved anti-inflammatory drugs are represented by nonsteroidal anti-inflammatory drugs (NSAID), glucocorticoids (SAID), and in some cases immunosuppressant and/or biological drugs. These agents are effective for the relief of the m...

Anti-Inflammatory Natural Products

1Laboratory of Immunology and Virology, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China 2Program in Cellular and Molecular Medicine, Boston Children’s Hospital and Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA 3Joslin Diabetes Center, Harvard Medical School, Boston, MA 02115, USA 4Division of Infectious Diseases, Cincinnati Children’s Hospit...

Anti-inflammatory Effects of NO-releasing Compounds

Anti-allergic and anti-inflammatory compounds from Aglaia andamanica leaves

The leaves from Aglaia andamanica were determined for their anti-allergic and anti-inflammatory effects using RBL2H3 and RAW264.7 cells, respectively. Among the isolated compounds, 24-epi-piscidinol A (5) exhibited the highest antiallergic activity against -hexosaminidase release with an IC50 value of 19.8 M, followed by (-)-yangambin (3, IC50 = 33.8 M), pyramidaglain A (8, IC50 = 37.1 M), ...